FL p53 mRNA makes Δ133p53 & Δ160p53

Maria Jose Lopez Iniesta et al.

With this study we have proved that short p 53 isoforms Δ133p53 and Δ160p53 can be translated from the FL transcript Translation of Δ133p53 and Δ160p53 from FL mRNA is IRES mediated, 5 ’cap independent. Drug usage changes the expression levels of these isoforms. Understanding the expression patterns and differential regulation of shorter p53 isoforms is crucial as they may contribute differently to p53 associated functions and to the development of diseases.

Full-length p53 mRNA is a frequent source of Δ133p53 and Δ160p53 protein isoforms