Research

Investigating RNA mutations and functions in cancer pathways.

 Research Keywords:

Cancer
p53
p53 mRNA
p53 isoforms
mRNA functions
RNA mutations

Latest Research:

See here

Main publications:

Alternative Mechanisms of mRNA Translation Initiation in Cellular Stress Response and Cancer. Lacerda R, Menezes J, Candeias MM. Adv Exp Med Biol. 2019;1157:117-132.
doi: 10.1007/978-3-030-19966-1_6.PMID: 31342440

Marques-Ramos A, Candeias MM*, Menezes J*, Lacerda R, Willcocks M, Teixeira A, Locker N, Romão L. Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition. RNA. 2017
doi: 10.1261/rna.063040.117 

badgef1000Candeias MM†, Hagiwara M & Matsuda M. Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis. EMBO Reports. 2016
doi: 10.15252/embr.201541956 

Gajjar M*, Candeias MM*, Malbert-Colas L, Mazars A, Fujita J, Olivares-Illana V & Fåhraeus R. The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage. Cancer Cell. 2012
doi: 10.1016/j.ccr.2011.11.016

Candeias MM†. The can and can’t dos of p53 RNA. Biochimie. 2011
doi: 10.1016/j.biochi.2011.06.010

Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias MM, Marullo S & Fåhraeus R. Endoplasmic reticulum stress induces G2 cell cycle arrest via mRNA translation of the p53 isoform p53/47. Molecular Cell. 2010
doi: 10.1016/j.molcel.2010.01.041

Naski N, Gajjar M, Bourougaa K, Malbert-Colas L, Fåhraeus R & Candeias MM†. The p53 mRNA-Mdm2 interaction. Cell Cycle. 2009
doi: 10.4161/cc.8.1.7326

Grover R*, Candeias MM*, Fåhraeus R & Das S. p53 and little brother p53/47: Linking IRES Activities with Protein Functions. Oncogene. 2009
doi: 10.1038/onc.2009.138

Candeias MM, Malbert-Colas L, Powell DJ, Daskalogianni C, Maslon MM, Naski N, Bourougaa K, Calvo F & Fåhraeus R. p53 mRNA controls p53 activity by managing Mdm2 functions. Nature Cell Biology. 2008
doi: 10.1038/ncb1770

Candeias MM*, Powell DJ*, Roubalova E, Apcher S, Bourougaa K, Vojtesek B, Bruzzoni- Giovanelli H & Fåhraeus R. Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation. Oncogene. 2006
doi: 10.1038/sj.onc.1209996

† corresponding author; * equally contributing authors