p53 isoforms and p53 protein stabilization

Maria Jose Lopez Iniesta et al.

In this study we have discovered that some p53 short isoforms silencing downregulates de expression of full length mutant P53 while they seem to upregulate its expression on full length wildtype p53. However we did not observe the opposite phenomenon when overexpressing these short isoforms in a wildtype p53 background. Further analyses into the mechanisms of isoform dependent p53 stabilization suggest an involvement for the p53 mRNA. These results could help shed light into the long time mystery of mutant p53 stabilization.

Shorter p53 isoforms: the new found link between cancer and p53 protein stabilization