Mutant p53 functions depend on truncated isoforms



Wild‐type p53 functions as a tumour suppressor while mutant p53 functions as an oncogene. In this new study we propose that this switch depends on Δ160p53, the most conserved isoform of p53, which is overexpressed in p53 mutant cells.

Here is a video by leading author Marco explaining the importance of the findings:


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